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A. Preformed Mediators in Granules. The acute reactions that occur as a result of mast cell activation are initiated as a consequence of degranulation and the generation of lipid-derived mediators, whereas more chronic mast cell-mediated symptomology is an outcome of the delayed generation of chemokines, cytokines and growth factors which follow enhanced gene expression. 22, 23 The process of ...

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Langerhans cell histiocytosis (LCH) is a clonal proliferative disease of Langerhans cells that express an immunophenotype positive for S100 and CD1a, and which contain cytoplasmic Birbeck granules. LCH occurs worldwide and most commonly develops in children aged 1-3 years, although disease can develop at any age.

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Introduction. Anti-proprotein convertase subtilisin kexin 9 (anti-PCSK9) monoclonal antibodies (Mab) are novel lipid-lowering drugs that have proven to be powerful in reducing low-density lipoprotein (LDL) cholesterol (LDL-C) on top of conventional therapy, and also to be safe in the short terms of clinical trials, as well as in the observation period of the trials extension.

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SD performed critical analysis and editing of the manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Introduction. The normal formation of the hippocampus is critical for learning and memory. It is positioned at the caudal-medial border of the neocortex and consists of the dentate gyrus, Cornus Ammonis fields CA1, CA3 and the subicular cortex.

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Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and a member of the Brain Research Institute at UCLA.

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Taxonomy of a platy coral association from the Late Cenomanian of the southern Corbières (Aude, France) Taxonomie d’une association de coraux « plats » du Cénomanien supérieur des Corbières méridionales (Aude, France)

Sep 07, 2009· Animals. Male SD rats weighing 250-300 g were purchased from the Shanghai Laboratory Animal Center of the Chinese Academy of Sciences and housed under constant conditions of temperature (20-22°C) and artificial lighting (12-h light-dark cycle) before taking part in the study.

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