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The Sod2 −/− CD1 mice develop a dilated cardiomyopathy at about 8 d of age (Li et al. 1995) while the Sod2 −/− B6 mice develop a basal ganglia and brain stem degeneration of the large neurons and die at ∼18 d (Lebovitz et al. 1996).
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For the practice recommendations provided in this statement, the classification of recommendations and the level of evidence determinations were taken from data available from clinical trials or registries about the usefulness/efficacy in different subpopulations.
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Nov 04, 2013· One of these proteins, HMGB1, which contains an HMG-domain, can inhibit repair of cisplatin-DNA 1,2-d(GpG) intrastrand cross-links by effectively blocking DNA repair proteins from accessing the adduct. 28 Overexpression of HMGB1 is thereby expected to increase the sensitivity of cells to cisplatin through such repair-shielding.
General roles of mitochondria in metabolism. In its most traditional definition, the mitochondrion is the energy-generating organelle of the cell, responsible for the final steps of metabolizing organic substances to produce energy for the cell in the form of adenosine triphosphate (ATP).
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HMG Coenzyme A Reductase Inhibitors (Statins) There is little data to suggest that this therapy should be initiated within the ED; however, early initiation (within 24 hours of presentation) of statin therapy is recommended in patients with an ACS or AMI (Class I, LOE C).
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